Custom Peptides
Cayman Chemical PXS-5505hydrochlorIde 10mg
A pan inhibitor of LOX and LOXL1-4 (IC50s = 0.493, 0.159, 0.57, 0.18, and 0.19 µM for fibroblast LOX and recombinant human LOXL1-4, respectively); selective for LOX and LOXL1-4 over DAO, VAP-1, MAO-A, and MAO-B (IC50s = >30 µM for all); reduces bleomycin-induced increases in dermal thickness and the levels of α-smooth muscle actin in a mouse model of systemic sclerosis at 15 mg/kg; reduces collagen crosslinking in KPC CAF 3D organotypic matrices; increases survival to a greater extent than gemcitabine alone when administered in combination with gemcitabine, reduces gemcitabine-induced increases in collagen levels and stiffness, and reduces liver metastatic burden in autochthonous KPC pancreatic ductal adenocarcinoma mouse models at 20 mg/kg
Cayman Chemical FexapotIdetrIfluoroacetAT 10mg
A peptide with anticancer activity; induces apoptosis in LNCaP prostate cancer cells at 2.5 mg/ml; reduces the numbers of prostate glandular epithelial cells without affecting other cell types and decreases prostate volume in rats when administered intraprostatically at 0.6 mg/animal per week
Cayman Chemical MyrIstoylCoenzyme AsodIum 10mg
A saturated acyl CoA; a substrate for N-myristoyltransferase during myristoylation; a substrate in the de novo synthesis of phosphatidylinositol
Cayman Chemical LN6023hydrochlorIde 10mg
A CXCR7 agonist; induces β-arrestin recruitment in a reporter assay using HEK293T cells (EC50 = 3.5 µM) but not in HEK293T cells expressing human CXCR4; reduces the surface levels of P-selectin in isolated and washed human platelets at 100 µM
Cayman Chemical trns-PetroselInIc AcId 10mg
A monounsaturated fatty acid; the isomer of oleic acid and trans isomer of petroselinic acid; has been found in cow, goat, and ewe milk fat as well as human breast milk; increases cellular content of triacylglycerols and cholesterol esters and upregulates transcription of genes involved in fatty acid synthesis, including SREBP-1c, ACACA, FASN, and SCD1, and cholesterol synthesis, including HMGCR, HMGCS1, FDFT1, and SREBP-2, in HepG2 cells at 100 μM
Cayman Chemical JWH 073 2naphthylN 2meth 10mg
Differs structurally from JWH 073 by having the naphthyl group attached at the 2' position and a 2-methylpropyl group in place of a butyl chain
Cayman Chemical JWH 018 2naphthylN 1 2dI 10mg
Differs from JWH 018 structurally by having a 1,2-dimethylpropyl chain, rather than a pentyl chain, extending from the indole group and the naphthyl moiety attached at its 2 position
Cayman Chemical S-PhenylmercapturIc AcId 10mg
A metabolite of benzene; used as a biomarker for benzene exposure; urinary concentrations up to 543 UG/g creatinine have been detected
Cayman Chemical EIcosapentaenoIc ACDpRoxI 10mg
An ω-3 fatty acid abundantly available in marine organisms; a poor substrate for COX-1 that is oxygenated by COX-1 and COX-2 at rates of about 5% and 30%, respectively, compared to arachidonic acid; has been shown to offer protection against coronary heart disease, thrombosis, ischemic brain injury, scaly dermatitis, and some inflammatory diseases
Cayman Chemical ArachIdonyl2Fluoroethylam 10mg
An analog of AEA in which the alcohol of the ethanolamide group has been replaced with a fluorine atom, which increases the binding affinity and selectivity for the CB1 receptor; in vivo activity is enhanced much less than the binding affinity, because it is rapidly hydrolyzed by FAAH
Cayman Chemical N-ArachIdonyl-L-AlnIn 10mg
Several different arachidonoyl amino acids, including NALA, have been isolated and characterized from bovine brain. The glycine congener (NAGly) was found to suppress formalin-induced pain in rats. NALA may act at the CB receptors and/or TRPV1, but has not yet been fully characterized.
Cayman Chemical 1 2DImyrIstoylsnglycero3 10mg
An anionic phospholipid containing myristic acid (14:0) inserted at the sn-1 and sn-2 positions
Cayman Chemical 2-NonylquInolIn-4 1H-on 10mg
A quinolone alkaloid; active against HCV (IC50 = 1.4 UG/ml) and L. gongylophorus; inhibits TPA- and A23187-induced NFAT activation in Jurkat cells but not LPS-induced NF-κB activation in RAW 264.7 cells (IC50s = 3.44 and >100 µM, respectively, in reporter assays)
Cayman Chemical -4-hydroxy Proprnololhy 10mg
An active metabolite of (±)-propranolol; decreases isoproterenol-induced tachycardia and vasodepression in cats (EC50 = 54 UG/kg); increases heart rate in catecholamine-depleted rats at 10 and 80 UG/kg; decreases heart rate, myocardial contractility, and cardiac output in dogs in a dose-dependent manner; reduces superoxide-induced lipid peroxidation in isolated rat hepatic microsomes (IC50 = 1.1 µM) and prevents superoxide-induced depletion of GSH levels in BAEC cells (EC50 = 1.2 µM)